High-fat diet-induced obesity augments the deleterious effects of estrogen deficiency on bone: Evidence from ovariectomized mice.

Moreover, calculation of HOMA‐IR (for insulin resistance) and HOMA‐β (for pancreatic β‐cell function) parameters showed a trend to increased HOMA‐IR value in HFD‐SHAM group that was accentuated in the HFD‐OVX group (Figure 2g ) combined with an trend to impaired insulin secretion as evaluated by the HOMA‐β ratio, which was more pronounced in the HFD‐OVX group as compared to the ND‐SHAM group (Figure 2h ).

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