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ADK-VR2, a cell line derived from a treatment-naïve patient with <i>SDC4-ROS1</i> fusion-positive primarily crizotinib-resistant NSCLC: a novel preclinical model for new drug development of ROS1-rearranged NSCLC.

Transl Lung Cancer Res · 2022 · PMC9742620 · PMID 36519016

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Crizotinib reduced the metastatic load although this decrease did not reach statistical significance compared to the control group ( Figure 3E ).

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