Unravelling selection signatures in a single dog breed suggests recent selection for morphological and behavioral traits.

No pathways were significantly enriched after accounting for multiple testing, however, Panther pathway analyses indicated nominally significant ( P < .05) functional enrichment of several pathways for the UK population: “heterotrimeric G‐protein signaling ‐Gi alpha and Gs alpha mediated” ( P = .01; genes: GRK4 , GRK7 , RGS12 , ADCY2 , ADRA2C , DRD2 ), “Alzheimer disease‐presenilin” ( P = .02; TRPC6 , MMP7 , MMP27 , RBPJ , MMP20 ), “heterotrimeric G‐protein signaling ‐Gq alpha and Go alpha mediated” ( P = .02; GRK4 , GRK7 , CACNA1A , RGS12 , DRD2 ), “ionotropic glutamate receptor” ( P = .03; CACNA1A , SLC17A8 , GRIA4 ), and “axon guidance mediated by semaphorins” ( P = .03; CRMP1 , FYN ).

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49 , 50 We found highly significant associations in between coat color and SNPs in this region showing evidence of selection (Table 2 , Figure S2 ).

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