Metastatic pancreatic neuroendocrine tumors feature elevated T cell infiltration.

Among the known chemokines, CCL5 (CC chemokine ligand 5, also known as RANTES), showed elevated mRNA levels in metastatic relative to localized tumors with marginal significance (log 2 fold change [FC] = 2.69, adjusted P = 0.079) ( Supplemental Figure 1 ).

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Tumor sizes were marginally different between these 2 groups — metastatic tumors were larger, although this did not reach statistical significance, likely due to the small sample size.

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