Impact of rheumatoid arthritis and methotrexate on pregnancy outcomes: retrospective cohort study of the Italian Society for Rheumatology.

Nevertheless, due to the low frequency of spontaneous abortion in this study (28 events observed), the association with past MTX use did not reach statistical significance at multivariate analysis (OR 2.52, 95% CI 0.86 to 7.36). 23 In contrast, in a prospective multicentre cohort study that evaluated the risk of spontaneous abortion and elective TOP in women treated with MTX during pregnancy or within 12 weeks before conception (preconception cohort), the HR for prec

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