Analysis of Sex-Specific Prostanoid Production Using a Mouse Model of Selective Cyclooxygenase-2 Inhibition.

67 Female mice also showed a greater abundance in COX1 mRNA expression compared to male mice, but this trend did not reach statistical significance. mPGES-1 was found to be partially involved in urinary PGE 2 production, since depletion of the mPges1 gene resulted in an approximate 50% reduction in urinary PGE 2 in both sexes, indicating that other pathways also lead to PGE 2 synthesis.

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