High spatial resolution analysis using automated indentation mapping differentiates biomechanical properties of normal vs. degenerated articular cartilage in mice.

NP and contrast enhanced XRM imaging yielded similar cartilage thickness distributions on both condyles ( Figure 2C ), demonstrating a highly significant correlation between paired values ( R =0.842, n=302, p < 0.0001) ( Figure 2D ).

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The lateral condyle values varied significantly per position (p < 0.0001), ranging from 0.07 to 0.15 N and showed a trend for higher values at outermost positions, with a slight decrease in force posteriorly.

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