Moreover, it has been shown that patients with CLL exhibit increased amounts of circulating immunosuppressive neutrophils (CD16 high CD62L dim ), and that, depending on the disease stage in the intermediate or advanced state, there is a strong trend toward an increase in the frequency of this TANs subset ( 59 ).
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The Yin-Yang of myeloid cells in the leukemic microenvironment: Immunological role and clinical implications.
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