extremely significantP < 0.01
According to the clinical score results ( Figure 4B ), an extremely significant higher score was observed in the day 12 group compared to the other groups ( P < 0.01), and the day 8 group showed an extremely significantly higher score compared with the CON and day 4 group ( P < 0.01), while no significant differences were observed between the CON and day 4 group ( P > 0.05).