The Bumphunter method ( Jaffe et al., 2012 ) was employed to further assess for differentially methylated regions (DMRs) in SARS-CoV-2 exposed samples (N = 4) compared to non-exposed (N = 4), using all nominally significant probes to determine segments within the genome which displayed consistently hyper or hypomethylated CpGs ( Peters et al., 2015 ). 2.1.6.
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