Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation.

Nat Rev Drug Discov · 2023 · PMC9768794 · PMID 36543887

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However, despite this, the treatment group receiving the highest dose showed a trend towards greater decline than the group receiving placebo across clinical outcome measures as well as an increase in NFL levels, suggesting increased neuronal injury 191 .

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