Clinical significance and long-term prognosis of ulcerative colitis patients with appendiceal orifice inflammation.

In a meta-analysis based on 12 trials including 2492 patients with mild to moderate UC, high-dose 5-ASA (> 3 g/dL) had a trend to be better than standard-dose 5-ASA (2–3 g/dL) for inducing clinical remission, although the difference in benefit did not reach statistical significance (risk ratio: 0.94 [0.88–1.01]) [ 17 ].

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