Mucosal and Systemic Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination Determined by Severity of Primary Infection.

After the first and second vaccinations, the low symptomatic group had less reactogenicity than the symptomatic group in nearly every category, and although the individual categories did not reach statistical significance, the low symptomatic group had fewer systemic symptoms than the symptomatic group when considering the number of systemic symptoms reported in each category of 1 more (71% versus 96%) or 2 or more (41% versus 77%) systemic symptoms ( P = 0.03 and P = 0.03, respectively).

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