Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice.

Consistently with histological observations, we did not find any negative effect of Senp2 ablation on aldosterone levels, but rather a positive trend with an increase in 18-hydroxy-corticosterone plasmatic concentration in Senp2 cKO males at 24 weeks and a trend toward upregulation of Cyp11b2 expression in Senp2 cKO female adrenals at 4 weeks (Supplementary Fig.

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The cortical proliferation index determined by scoring the number of Ki67- or BrdU-positive cells ruled out the contribution of a decreased proliferation rate to the hypoplastic phenotype, but rather showed a trend toward increased cell division in mutant adrenals (Supplementary Fig.

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