13 In addition, when we examined the expression of activation (CD38 and HLA-DR) and exhaustion (PD-1 and CTLA-4) markers on CD8 + and CD4 + T cells, the frequencies of CD38 + HLA-DR + cells, PD-1 + cells, and CTLA + cells among CD8 + and CD4 + T cells tended to be transiently increased on day 3 and then restored to basal levels after day 7, although the differences did not reach statistical significance ( supplemental Figure 2 A-C).
← all excerpts
A single administration of hIL-7-hyFc induces long-lasting T-cell expansion with maintained effector functions.
1
—
—