Safety and efficacy of a cardiovascular polypill in people at high and very high risk without a previous cardiovascular event: the international VULCANO randomised clinical trial.

Finally, although the CNIC-polypill decreased triglyceride levels by 3.5% while they increased by 1.5% with usual care, the adjusted mean difference for the change between treatments did not reach statistical significance (Fig. 3 f and Additional file 1 : Table S5).

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Finally, we observed a trend toward a greater increase in the rate of patients with BP or LDL-c controlled at the end of the study and a larger decrease of borderline significance in the SCORE and PCE predicted 10-year CV risk in patients on the polypill approach compared with patients who continued with the multipill strategy.

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