Sialyltransferase Inhibitor Ac₅3F_axNeu5Ac Reverts the Malignant Phenotype of Pancreatic Cancer Cells, and Reduces Tumor Volume and Favors T-Cell Infiltrates in Mice.

Regarding mice survival, the results showed a trend of 10 or 20 mg/kg of Ac 5 3F ax Neu5Ac administration to increase median mice survival time, although it was not statistically significant ( Figure 5 e). 3.6.

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The percentage of myeloid regulatory cells (granulocytes and monocytes) in the 10 mg/kg group showed an increasing trend, while the percentage of B cells and macrophages remained unaltered in that group with respect to the control one ( Figure 6 h–k).

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