Depression-Associated <i>Negr1</i> Gene-Deficiency Induces Alterations in the Monoaminergic Neurotransmission Enhancing Time-Dependent Sensitization to Amphetamine in Male Mice.

Escitalopram induced a decrease in serotonin turnover in both genotypes, but this effect was highly significant only in the raphe of Negr1 −/− mice.

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In Negr1 −/− mice, on the contrary, these transcripts showed a trend towards amphetamine-induced reduction, indicating altered molecular reactivity to amphetamine in the brains of Negr1 −/− mice.

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