Tumoricidal, Temozolomide- and Radiation-Sensitizing Effects of K<sub>Ca</sub>3.1 K<sup>+</sup> Channel Targeting In Vitro Are Dependent on Glioma Cell Line and Stem Cell Fraction.

Cancers (Basel) · 2022 · PMC9776522 · PMID 36551685

Europe PMC DOI

hedged sentences

0.0560

closest p · 1.1× alpha

0.0649

boldest claim

The sentences

showed a trendp = 0.056so close (0.05 < p ≤ 0.1)

In limited dilution assay with stem cell-enriched NSC-grown SMA-560 cells, temozolomide showed a trend ( p = 0.056) towards radio-sensitization of the cells at high irradiation doses ( Figure 5 D).

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did not quite reach statistical significancep = 0.0649so close (0.05 < p ≤ 0.1)

A similar trend was found in U-251MG; however, TRAM-34′s effect in NSC medium did not quite reach statistical significance (see Figure 9 B,C; p = 0.0649).

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almost significantno p-value reported

As a matter of fact, a significant and almost significant higher number of NSC medium-grown and 1-EBIO-treated cells exhibited a large inward conductance and a high TRAM-34-sensitive conductance fraction, respectively, than 1-EBIO-treated DMEM medium cultivated cells.

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