Sodium Butyrate Supplementation Modulates Neuroinflammatory Response Aggravated by Antibiotic Treatment in a Mouse Model of Binge-like Ethanol Drinking.

Parallel to IHC findings, ethanol induced an increase in Iba-1 mRNA level with a statistical trend.

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Without ABX treatment, SB supplementation reversed the ethanol-induced increases in mRNA levels for MCP-1, IL-1β and IL-10 ( Figure 2 A,D,E; SB-DID vs H 2 O-DID) and caused reduction in TNF-α and IL-6 levels which however did not reach statistical significance ( Figure 2 B,C; SB-DID vs H 2 O-DID).

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