NFκB-Mediated Mechanisms Drive PEDF Expression and Function in Pre- and Post-Menopausal Oestrogen Levels in Breast Cancer.

In MDA-MB-231, all treatments prevented colony growth to a similar extent under pre-menopausal conditions, with a slight trend towards JSH-23 treatment alone having the greatest effect on reducing colony growth, however this did not reach statistical significance ( Figure 4 I,J,Q).

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PEDF also slightly increased CXCR4 expression under pre-menopausal conditions in both cell lines, although this did not reach statistical significance ( Figure 1 a).

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