For hypertrophic markers, COL10A1 (FC = 0.23; P = 1.05 × 10 −3 ) was significantly downregulated after IOP treatment, while downregulation of COL1A1 (FC = 0.11; P = 5.29 × 10 −2 ) and ALPL (FC = 0.03; P = 5.71 × 10 −2 ) did not reach statistical significance.
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Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes.
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