Association of glucagon-like peptide-1 receptor agonists with cardiac arrhythmias in patients with type 2 diabetes or obesity: a systematic review and meta-analysis of randomized controlled trials.

Diabetol Metab Syndr · 2022 · PMC9791739 · PMID 36572913

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did not reach statistical significanceno p-value reported

According to our findings, the incidence of AFL appeared to be lower in the GLP-1RAs group than in the control group, but the difference did not reach statistical significance.

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a slight trendno p-value reported

A slight trend toward an increased risk of AF was observed with dulaglutide, whereas the trend was not robust owing to the overweighting of the REWIND trial.

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an increasing trendno p-value reported

In further subgroup analyses, we observed an increasing trend toward incident AF with dulaglutide (RR 1.40, 95% CI 1.03–1.90) while an inverse trend with oral semaglutide (RR 0.43, 95% CI 0.21–0.87).

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marginally significantno p-value reported

Interestingly, subcutaneous semaglutide also seemed to be associated with a small, albeit marginally significant reduction in AF events.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.