When focusing on typical butyric acid producers like the Lachnospiraceae and Ruminococcaceae families 18 , one genus in the Ruminococcaceae family ( Anaerotruncus ) and five genera in the Lachnospiraceae family ( Lachnospiraceae UCG_003 , Eubacterium eligens group , Coprococcus , Lachnospiraceae CAG_56 and Ruminococcus gnavus group ) had nominally significant different abundance in patients and controls, but as the first four genera were more abundant in controls, and the latter two in patients, we could not show a consistent pattern (Supplemental Fig. 2 ).
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Fecal level of butyric acid, a microbiome-derived metabolite, is increased in patients with severe carotid atherosclerosis.
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