The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus.

At the earlier time point, the two groups had comparable levels of anti-dsDNA of IgG2a isotype ( Figure 4B ), whereas GC blocked 564Igi mice presented with slightly elevated levels of anti-dsDNA IgG2b, although this difference did not reach statistical significance ( Figure 4C ).

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