<i>N</i>-acetylcysteine attenuates oxidative stress-mediated cell viability loss induced by dimethyl sulfoxide in cryopreservation of human nucleus pulposus cells: A potential solution for mass production.

JOR Spine · 2022 · PMC9799083 · PMID 36601378

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Interestingly, exposure to DMSO in a dose‐dependent manner significantly downregulated gene expression of antioxidant enzymes SOD1 and SOD2 and showed a clear trend of reduction for SOD3 mRNA level (Figure 3A–C ).

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