Pilot studies using the calorie restriction mimetic, metformin, which greatly re-configures metabolism, demonstrated enhanced responsiveness to malignant melanoma immunotherapy, though these failed to reach statistical significance, likely due to the small sample size. 26 With the recognition that diet can impact responsiveness to immunotherapy, the question becomes not simply which diet can attenuate intestinal inflammation but also which dietary intervention(s) best potentiates existing IBD immunotherapy in specific IBD patient subcohorts.
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