87 , 88 , 89 However, studies have shown that the enrichment of Akkermansia may play an important role in the progression of PD, as a significant trend effect for disease duration on increasing levels of Akkermansia was found. 25 , 27 , 33 , 90 Intriguingly, an increase in Akkermansia was also reported in multiple system atrophy, progressive supranuclear palsy, 33 Alzheimer's disease, and multiple sclerosis, 52 suggesting that this finding may not be specific to PD.
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