Organic Anion Transporter Gene Variants Associated With Plasma Exposure and Long-Term Response to Atrasentan in Patients With Diabetic Kidney Disease.

Clin Pharmacol Ther · 2022 · PMC9804438 · PMID 35892316

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a clear trendno p-value reported

Despite considerable variability in plasma exposure within each SLCO1B1 genotype, there was a clear trend in higher atrasentan plasma exposure with reduced hepatic uptake for the rarer variant SLCO1B1 genotypes.

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