Single-cell resolved ploidy and chromosomal aberrations in nonalcoholic steatohepatitis-(NASH) induced hepatocellular carcinoma and its precursor lesions.

Other histopathological parameters such as tumor size, angioinvasion and higher tumor stage were not significantly correlated with the chromosomal instability, though a positive trend was detected (Fig. 2 C).

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The correlation of ploidy in NAFLD/NASH specimens with macrosteatosis, the nonalcoholic steatohepatitis score (NAS) showed a trend towards decreasing ploidy, i.e. an inverse association but not a significant correlation (Fig. 3 C).

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