The role of lymphoid tissue SPARC in the pathogenesis and response to treatment of multiple myeloma.

Adding FDCs to the lymphocyte cultures without LPS stimulation or IC treatment tended to reduce oncogenes’ expression; however, this reduction did not reach statistical significance.

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BM PC infiltration reflects higher disease burden ( 51 ) and worse outcome in MM, and our results obtained from the BM biopsies are in concordance with prior studies on the blood from MM patients reporting an overall trend to downregulation in the advanced stage of the disease ( 52 ).

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Generally, the trends in oncogenes’ expression were not statistically significant apart from CCND1 where IC treatment significantly upregulated its expression as well as IRF4 and CCND1 in LPS-stimulated cultures where the p value was close to significance (0.059 and 0.073, respectively).

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