Markers of extracellular matrix remodeling and systemic inflammation in patients with heritable thoracic aortic diseases.

As shown in Supplementary Figure 1 , whereas these five patients had numerically higher levels of MMP-9 and PTX3 than healthy controls, and for PTX3 with similar mean levels as in the symptomatic patients, the differences did not reach statistical significance, most probably reflecting the low number of phenotype-negative patients.

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