Blood-nerve barrier disruption and coagulation system activation induced by mechanical compression injury participate in the peripheral sensitization of trigeminal neuralgia.

However, the mechanical pain thresholds of the sham group showed a trend opposite that of the other three groups, i.e., they declined to the nadir on POD 1, then gradually increased and approached the baseline values from PODs 3 to 7, which was similar to the behavior test results described above.

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