Attenuated transcriptional response to pro-inflammatory cytokines in schizophrenia hiPSC-derived neural progenitor cells.

Brain Behav Immun · 2022 · PMC9810540 · PMID 35716830

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nominally significantno p-value reported

The top five gene sets were enriched among nominally significant upregulated genes in this comparison ( Fig. 2 B), and the gene set with the lowest p- value was ‘Lek2015 loss-of-function (90)’ ( FDR = 0.00098; normalized enrichment score (NES) = 1.36; genes in gene set = 3007), which contains 3007 genes that are intolerant to loss-of-function variants.

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