Extent of Low-density Lipoprotein Cholesterol Reduction and All-cause and Cardiovascular Mortality Benefit: A Systematic Review and Meta-analysis.

In both unadjusted and adjusted meta-regression analysis, the ARDs for stroke risk increased significantly ( P = 0.003 to 0.005) for each 20% LDL-C percentage reduction; a 9% increase in RRs for stroke was of borderline significance ( P = 0.05 and 0.07 respectively) but a significant 13% increase after further adjustment to CV mortality rate ( P = 0.003) (see eFigure 11 , Supplemental Digital Content , http://links.lww.com/JCVP/A875 ).

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In unadjusted and adjusted meta-regression analyses, we did not find a significant trend toward decrease in both ARDs and RRs for all-cause mortality according to percentage LDL-C reduction (Fig. 1 ).

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