The CD4 + T cells of MS patients showed a trend toward a higher maximum VAF, corresponding to a possibly larger clonal size, both for all possibly damaging variants and for possibly damaging variants in expressed genes ( p = 0.048, Figures 2F, I ), although this does not survive multiple testing correction. 3.3 Somatic variants have characteristics indicating deleteriousness but are enriched in lowly expressed genes Our dataset obtained from investigating the whole exome allows unbiased evaluation of somatic variant characteristics.
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Frequent somatic mosaicism in T lymphocyte subsets in individuals with and without multiple sclerosis.
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