Integrative Clinical and DNA Methylation Analyses in a Population-Based Cohort Identifies <i>CDH17</i> and <i>LRP2</i> as Risk Recurrence Factors in Stage II Colon Cancer.

By contrast, the iTreg subset was negatively correlated with LRP2 ‘high methylation’ status, together with a tendency towards depletion of the CD4 T lymphocyte subset, although this did not reach statistical significance ( Figure 4 d and Supplementary Figure S4b ).

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