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Advanced Maternal Age Differentially Affects Embryonic Tissues with the Most Severe Impact on the Developing Brain.

Cells · 2022 · PMC9818809 · PMID 36611870

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a clear trendno p-value reported
Moreover, there was a clear trend that this down-regulation became more pronounced as maternal age advanced further.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.