nominally significantp < 0.05
An SNP was considered to have a pleiotropic effect on two traits when the p -value for the test statistic from the cross-phenotype analysis was at least one order of magnitude more significant than the p -values for both traits and the SNP was at least nominally significant ( p < 0.05) with each of the individual traits [ 13 , 14 ]. 2.4.