Target-Specific Nanoparticle Polyplex Down-Regulates Mutant <i>Kras</i> to Prevent Pancreatic Carcinogenesis and Halt Tumor Progression.

Int J Mol Sci · 2023 · PMC9821664 · PMID 36614194

Europe PMC DOI

hedged sentence

0.0601

closest p · 1.2× alpha

0.0601

boldest claim

The sentences

did not reach statistical significancep = 0.0601so close (0.05 < p ≤ 0.1)

Mice treated with the targeted NP that was loaded with muKRAS siRNA had 50% fewer metastases per mouse, but the difference did not reach statistical significance ( p = 0.0601) at the dose used (240 nM).

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