Transcriptional activity mediated by β-CATENIN and TCF/LEF family members is completely dispensable for survival and propagation of multiple human colorectal cancer cell lines.

In cell lines with an active WNT/β-CATENIN pathway (HT29, HCT116, SW480) and provided that the gene under investigation was expressed, we observed that eliminating β-CATENIN was paralleled by reduced expression of AXIN2 , ASCL2 , and TERT , albeit the reduction in TERT expression did not reach statistical significance in HT29 cells (Fig. 4 ).

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