G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects.

Nucleic Acids Res · 2022 · PMC9825156 · PMID 36511872

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Cells treated with S10+2, S10_L6 and S30 showed a trend toward increased FXN mRNA expression levels (transcripts per million (TPM), Figure 7D ).

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