Patient-specific identification of genome-wide DNA-methylation differences between intracranial and extracranial melanoma metastases.

7 A): (i) the majority of genes with decreased gene body methylation showed a trend towards increased expression in intra- compared to extracranial metastases (8 of 11 genes: CACNA2D3 , DUSP6 , EIF4B , GDF15 , IGF1R , PRKCA , RASGRF1 , SGK1 ), (ii) the other three genes with decreased gene body methylation showed a trend towards decreased expression in intra- compared to extracranial metastases (3 of 11 genes: JAK3 , TNR , TNXB ), and (iii) both genes with increased gene body methylation ( BMP4 , MECOM ) showed a trend towards decreased expression in intra- compared to extracranial metastases.

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