Barely Significant
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CYP2C19 Plays a Major Role in the Hepatic <i>N</i>-Oxidation of Cotinine.

Drug Metab Dispos · 2023 · PMC9832378 · PMID 35197312

Europe PMCDOI
1
hedged sentence
0.0890
closest p · 1.8× alpha
0.0890
boldest claim

The sentences

approached significancep = 0.089so close (0.05 < p ≤ 0.1)
While the decreases observed in the different CYP2C19 metabolizing groups were not significant ( p trend = 0.26), the difference approached significance ( p = 0.089) when comparing the combined UM 2C19 + EM 2C19 groups (11.9 ± 6.4 pmol•min −1 •mg −1 microsomal protein) versus the combined IM 2C19 + PM 2C19 groups (10.1 ± 5.3 pmol•min −1 •mg −1 microsomal protein; Fig. 4B ).

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