Smoking and diabetes attenuate beneficial effects of PSCK9 inhibitors on arterial wall properties in patients with very high lipoprotein (a) levels.

Atheroscler Plus · 2022 · PMC9833244 · PMID 36643800

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0900

boldest claim

The sentences

borderline significantp = 0.060so close (0.05 < p ≤ 0.1)

The mean ages of the groups showed borderline significant differences (47.5 ± 9.5, 52.8 ± 8.2, 49.9 ± 8.9 years, respectively; p = 0.060).

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of borderline significancep = 0.090so close (0.05 < p ≤ 0.1)

For diabetes mellitus type II, there were 7 (20.0%), 6 (17.1%) and 1 (2.9%) patients across the groups, respectively; the differences between the groups here were of borderline significance (chi-squared test, p = 0.090).

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did not reach statistical significanceno p-value reported

[ 49 ] in Japanese patients with acute coronary syndrome and hypercholesterolaemia, they reported a trend to greater percent reduction in normalised total atheroma volume in the patients treated with alirocumab compared to standard therapy (i.e., atorvastatin or rosuvastatin), although as they indicated, this did not reach statistical significance.

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