Semaglutide treatment attenuates vessel remodelling in ApoE-/- mice following vascular injury and blood flow perturbation.

In a combined analysis of study A and Study B, there was a borderline significant increase of Mac-2 area of ≈3.8-fold in the vehicle-treated group compared with control ( p = 0.0539), and treatment with semaglutide reduced the Mac-2 area significantly with ≈67% ( p = 0.0135, Table 1 ). 3.6.

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Tunica intima area was also elevated in vehicle-treated mice compared to control in study B, where electric injury was combined with application of a constrictive cuff for 6 h, but it did not reach statistical significance ( Fig. 3 B).

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