Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis.

CF mice, compared with WT mice, had distal airspace enlargement, which developed in the absence of external inflammatory triggers at T0, as reported previously, 52 but the difference did not reach statistical significance ( Figures 3Aa – 3Ad , 3Ba – 3Bd , and 3C ).

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