New potential for an old kid on the block: Impact of premorbid metformin use on lactate kinetics, kidney injury and mortality in sepsis and septic shock, an observational study.

showed that in critically ill patients, changes in blood lactate kinetics were clearly significant after 6 hrs in many studies and after 12 hrs in most. 27 Lastly, as we conducted a single‐centred study in a large nonacademic ICU, generalization to other institutions may be inherently limited.

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