We further analyzed clinically stratified breast cancer cases, including 8 cases of TNBC, 6 cases with HR - HER2 + , and 18 cases of HR + , and found that all subtypes of breast tumors showed a trend of a positive correlation between CD10 + CAFs and CCL18 + TAMs, but the P values did not indicate statistical significance due to the limited number of cases (Supplementary Fig. 2H ).
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CCL18 signaling from tumor-associated macrophages activates fibroblasts to adopt a chemoresistance-inducing phenotype.
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