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Genome-wide CRISPR screens identify CD48 defining susceptibility to NK cytotoxicity in peripheral T-cell lymphomas.

Blood · 2022 · PMC9837448 · PMID 35921533

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37 , 38 In our CRISPR screen, the enrichments of NKG2D ligands (MICA, MICB, ULBP1, ULBP2, UBLP3, and RAETL1) and DNAM-1 ligands (PVRL1 and PVRL2) were minor and did not reach statistical significance in the MAGeCK algorithm (data not shown), implying molecular compensation among NKG2D ligands and DNAM-1 ligands.

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